The Xie Group @ Northwest A&F University

53. A de novo synthesis of the bisindole alkaloid geissolosimine: collective synthesis of geissoschizoline, akuammicine, (16S)-deshydroxymethylstemmadenine and Aspidospermatan alkaloids. Jiahang Yan,‡Yanxia Zhen,‡   Pengyan Wang,‡   Yimeng Han,   Huanhuan Zou,   Junhan Chen,   Weigang He*   and   Weiqing Xie*, Org. Chem. Front., 2024, Advance Article.‍‍‍‍‍‍‍‍‍‍

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52. Gram-scale synthesis of alstoscholarinoid B via a bio-inspired strategy.   Long He,‡   Wenting Zhang,‡   Xiaocheng Zhang,‡   Xiaohui Wu,   Yimeng Han,   Jiahang Yan*   and   Weiqing Xie*, Org. Biomol. Chem. 2023, 21, 9346-9355‍‍‍‍‍‍‍‍‍‍

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51. Asymmetric Synthesis of (+)-Vellosimine Enabled by a Sequential Nucleophilic Addition/Cyclization Process.   Huanhuan Zou, Jiahang Yan*, Xiaocheng Zhang, Xiaohui Wu, Jiyou Huo, Yuanzhen Xu*, and Weiqing Xie*, ‍‍Org. Lett., 2023, 25, 8215–8219‍‍.‍‍‍‍‍‍‍‍

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50. Stereodivergent Construction of Contiguous Quaternary Carbon Centers Enabled by Asymmetric Catalysis. Jiyou Huo, Xiuhuan Li, Qianhu Chen, Pengpeng Gao, Yi Hou, Pan Lei, Huanhuan Zou, Jiahang Yan*, Xiaolong Wan*, and Weiqing Xie*, ‍‍ACS Catalysis., 2023, 13, 15007-15012‍.‍‍‍‍‍‍‍‍

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49. Catalytic Asymmetric Reverse Prenylation of Indol-2-one Enabled a Synthesis of (−)-Debromoflustramine A. Yi Hou, Jiyou Huo, Ruoxin Li, Jun Hou, Pan Lei, Hongbo Wei*, and Weiqing Xie*, ‍‍Org. Lett. 2023, 25, 6949–6953.‍‍‍‍‍‍‍‍

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48. A formal synthesis of (–)-erinacine B enabled by asymmetric organocatalysis. Jiahang Yan,‡   Dongyang Xu,‡   Zhiqiang Zhou,‡   Long He,   Jin-Ming Gao,*   Hongbo Wei*   and   Weiqing Xie*, ‍‍Chem. Commun., 2023, 59, 7092-7095‍‍.‍‍‍‍‍‍‍‍

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47. Catalytic Asymmetric Friedel–Crafts Alkylation of Indole via In Situ Generated Indol-2-one. Yuanai Fei, Jun Hou, Huiying Song, Mei-li Yang, Pan Lei, Xiayu Ge, Hongbo Wei*, Yuanzhen Xu*, Weiqing Xie*, ‍Eur. J. Org. Chem. 2023, 26, e202300122‍.‍‍‍‍‍‍‍‍

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46. Catalytic asymmetric construction of C2-symmetric contiguous quaternary carbon centers enabled a concise synthesis of (−)-chimonanthidine and (−)-folicanthine

. Yuanzhen Xu, Pan Lei, Yuannai Fei, Yi Hou, Guzhou Chen, Zhiqiang Zhou, Huanhuan Zou, Hongbo Wei* and Weiqing Xie*, Tetrahedron Lett., 2023, 114, 154261.‍‍‍‍‍‍

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45. Convergent Synthesis of Enantioenriched ortho-Fused Tricyclic Diketones via Catalytic Asymmetric Intramolecular Vinylogous Aldol Condensation. Zhiqiang Zhou, Dongyang Xu, Wei Jiang, Junhan Chen, Yanxia Zhen, Jiyou Huo, Jiahang Yan*, Jinming Gao* and Weiqing Xie*, Org. Lett. 2022, 24, 49, 9017-9022.‍‍‍‍‍‍‍

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44. Enantioselective direct vinylogous Michael addition for constructing enantioenriched γ,γ-dialkyl substituted butyrolactams and octahydroindoles. Jiahang Yan, Wenting Zhang, Qiaoqiao He, Jun Hou,   Hongxin Zeng, Hongbo Wei* and Weiqing Xie*, Org. Biomol. Chem., 2022, 20, 2387-2391.‍

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43. A concise synthesis of herbertenolide. Jiadong Hu,    Kai Ji,   Lihong Yan,   Siyu Yang,   Yin Li,   Wen Wen,   Le Chen,   Xiaohui Wu,   Youcai Hu and   Weiqing Xie*, Org. Biomol. Chem., 2022, 20, 2205-2208.

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42. The applications of catalytic asymmetric halocyclization in natural product synthesis. Jiahang Yan, Zhiqiang Zhou, Qiaoqiao He,a   Guzhou Chen, Hongbo Wei * and   Weiqing Xie*, Org. Chem. Front., 2022, 9, 499-516.

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41. 2,2,2-Trifluroenthanol promoted synthesis of unsymmetrical ureas from dioxazolones and amines via tandem lossen rearrangement/condensation process, Jian Li, Wang He, Pan Lei, Jiacheng Song, Jiyou Huo, Hongbo Wei* Hongjin Bai* and Weiqing Xie*, Synth. Commun., 2021, 51(23): 3590-3600.‍

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40. A Concise Synthesis of (-)-Dihydrospirotryprostatin B via Tandem Michael Addition. Hengqian Song, Jiacheng Song, Lihong Yan,   Weigang He, Pengyan Wang, Yuanzhen Xu,   Hongbo Wei,* Weiqing Xie* , Tetrahedron Lett. 2021, 85(23): 153486-153489.

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39.   An Asymmetric Synthesis of (+)-Isostrychnine Based on CatalyticAsymmetric Tandem Double Michael Addition. Pengyan Wang,   Junhan Chen,   Weigang He, Jiacheng Song,   Hengqian Song, Hongbo Wei*, and Weiqing Xie* Org. Lett. 2021,23, 14, 5476–5479‍

38. The catalytic asymmetric dearomatization of tryptamine for accessing meso-contiguous quaternary carbon centers of oligomeric cyclotryptamine alkaloids: a formal synthesis of hodgkinsine B. Hongbo Wei, Guzhou Chen, Huanhuan Zou, Zhiqiang Zhou, Pan Lei, Jiahang Yan and   Weiqing Xie*. Org. Chem. Front., 2021, 8(13): 3255-3259.

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37. Au(I)-Catalyzed Domino Cyclization of 1,6-Diynes Incorporated with Indole. Guzhou Chen, Peng-Yu Liu, Huanhuan Zou, Jiadong Hu, Xiaowu Fang, Dongyang Xu, Yu-Peng He*, Hongbo Wei*, and Weiqing Xie*. Org. Lett. 2021, 23, 2279–2284.

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36. Asymmetric Synthesis of ent-Fissistigmatin C. Dongyang Xu, Jiadong Hu, Le Chen, Lu Chen, Jiang Su, Jinjin Yang, Siyu Deng, Hongli Zhang*,and Weiqing Xie*. ‍Org. Lett. 2021, 23, 93–96.‍

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35. Asymmetricsynthesis of 9-alkyl tetrahydroxanthenones via tandem asymmetric Michael/cyclization promoted by chiral phosphoric acid. Yu-Qi Gao, Yi Hou, Junhan Chen,

Yanxia Zhen, Dongyang Xu, Hongli Zhang, Hongbo Wei and Weiqing Xie*. Org. Biomol. Chem., 2021, 19, 348–354‍.‍

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34. Highly enantioselective addition of aliphatic aldehydes to 2-hydroxychalcone enabled by cooperative organocatalysts, Jiadong Hu+, Yu Qi Gao+, Dongyang Xu, Le Chen, Wen Wen, Yi Hou, Lu Chen and Weiqing Xie*. Chem. Commun., 2020, 56, 10018-10021.‍

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‍33. Advances in the Synthesis of Anislactone-type Sesquiterpenes. Jian Li, Long He, Zhiqiang Zhou, Yanxia Zhen, Weiqing Xie.Chin. J. Org. Chem., 2020, ‍40, 3166-3176.

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32. Visible-light driven synthesis of polycyclic benzo[d][1,3]oxazocine from 2-aminochalcone. Yu-Qi Gao,   Yi Hou,   Liming Zhu,   Junhan Chen,   Ruoxin Li,   Sheng-Yong Zhang,*   Yu-Peng He*   and   Weiqing Xie*. Chem. Commun., 2020,56, 6739-6742‍.

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31. Recent progress in the total synthesis of Strychnos alkaloids. Weigang He, Pengyan Wang, Junhan Chen, Weiqing Xie*. Org. Biomol. Chem., 2020, 18, 1046–1056.‍


30. A bio-inspired synthesis of hybrid flavonoids from 2-hydroxychalcone driven by visible light. Yu-Qi Gao, Yi Hou, Liming Zhu, Guzhou Chen, Dongyang Xu, Sheng-Yong Zhang, Yupeng He, Weiqing Xie*. RSC Advances, 2019, 9(50), 29005-29009.

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29. Concise syntheses of (+)-austrodoral and (+)-austrodoric acid Based on H2O2 mediated oxidative ring contraction. Hongbo Wei, Hongli Zhang, Shoule Han, Shan Mu, Ke Huang, Guzhou Chen, Weiqing Xie*. Tetrahedron Letters, 2019, 60(35), 150973‍.

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28. Carboxylate phosphabetaine as a bifunctional organocatalyst for the intramolecular ring opening of oxetane. Dongyang Xu,‡ Hongbo Wei,‡ Yanxia Zhen, Yu-Qi Gao, Ruoxin Li, Xingzhou Li, Yupeng He, Zhong Zhang and Weiqing Xie*.   ‍Org. Chem. Front., 2019, 6, 1681-1685‍.‍

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27. Highly Enantioselective Tandem Michael Addition of Tryptamine-Derived Oxindoles to Alkynones: Concise Synthesis of Strychnos Alkaloids. Weigang He,† Jiadong Hu,† Pengyan Wang,† Le Chen, Kai Ji, Siyu Yang, Yin Li, Zhilong Xie and Weiqing Xie*. Angew. Chem. Int. Ed., 2018, 57(14), 3806-3809.‍

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26. New Strategy for Forging Contiguous Quaternary Carbon Centers via H2O2-Mediated Ring Contraction. Jiadong Hu, Xin Yu, Weiqing Xie*. Synlett 2017; 28(19): 2517-2524.‍

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25. Facile Access to 2,2-Disubstituted Indolin-3-ones via Cascade Fischer Indolization/Claisen Rearrangement Reaction. Zilei Xia, Jiadong Hu, Yu-Qi Gao, Qizheng Yao* and Weiqing Xie*. Chem. Commun. 2017, 53 (54), 7485-7488.

24. A Re2O7 catalyzed cycloetherification of monoallylic diols. Xiaolong Wan+, Jiadong Hu+, Dongyang Xu, Yang Shang, Yanxia Zhen, Chenchen Hu, Fan Xiao, Yu-Peng He*, Yisheng Lai*, Weiqing Xie*.Tetrahedron Lett., 2017,58(12):1090-1093.

23. Stereospecific Construction of Contiguous Quaternary All-Carbon Centers by Oxidative Ring Contraction. Xin Yu+, Jiadong Hu+, Zhigao Shen, Hui Zhang, Jin-Ming Gao, and Weiqing Xie*. Angew. Chem. Int. Ed., 2017, 56(1), 350-353‍


22. Tandem allylic alcohol isomerization/oxo-Michael addition reaction promoted by Re2O7. Jiadong Hu, Dongyang Xu, Qiang Zhang, Yang Shang, Mumin Shi, Yucui Huangfu, Leilei Liu, Rong liang, Yisheng Lai,* Yupeng He,* Jin-ming Gao and Weiqing Xie*. RSC Advances 2016, 6, (58), 52583-52586.‍

21. Enantioselective Bromo-oxycyclization of Silanol, Zilei Xia, Jiadong Hu, Zhigao Shen, Xiaolong Wan, Qizheng Yao, Yisheng Lai, Jin-Ming Gao, Weiqing Xie*, Org. Lett., 2016, 18 (1), pp 80–83‍

20. Chiral Ion-Pair Organocatalyst Promotes Highly Enantioselective 3-exo Iodo-cycloetherification of Allyl Alcohols, Zhigao Shen, Xixian Pan, Yisheng Lai, Jiadong Hu, Xiaolong Wan, Xiaoge Li, Hui Zhang, Weiqing Xie*, Chem. Sci., 2015, 6, 6986-6990

19. Total Synthesis of (-)-Conolutinine. Xiangyang Feng, Guangde Jiang, Zilei Xia, Jiadong Hu, Xiaolong Wan, Jin-Ming Gao, Yisheng Lai*, Weiqing Xie*, Org. Lett., 2015, 17 (18), pp 4428–4431

18. Synthesis of Naked Amino-Pyrroloindoline via Direct Aminocyclization of Tryptamine,Zhigao Shen, Zilei Xia, Huijun Zhao, Jiadong Hu, Xiaolong Wan, Yisheng Lai,* Chen Zhu*, Weiqing Xie*, Org. Biomol. Chem., 2015, 13, 5381-5384

17. Re2O7 catalyzed dienone-phenol rearrangement, Zilei Xia+, Jiadong Hu+, Zhigao Shen, Qizheng Yao*, Weiqing Xie*,RSC Adv., 2015, 5, 38499-38502.

16. Oxidative Rearrangement of Malondialdehyde: Substrate Scope and Mechanistic Insights, Xin Yu, Zheng Liu, Zilei Xia, Zhigao Shen, Xixian Pan, Hui Zhang* and Weiqing Xie*, RSC Adv., 2014, 4, 53397-53401.

15. Decarboxylative Hydroamination of Propiolic Acids with N-Heterocycles under Transition-Metal-Free Condition, Xixian Pan, Hui Zhang,* Xin Yu, Xiaolong Wan, Weiqing Xie*,Synlett. 2014, 46, 2057-2064.

14. Highly Asymmetric Bromocyclization of Tryptophol: Unexpected Accelerating Effect of DABCO-derived Bromine Complex, Huan Liu, Guangde Jiang, Xixian Pan, Xiaolong Wan, Yisheng Lai,*, Dawei Ma* and Weiqing Xie*, Org. Lett.2014, 16, 1908–1911.

13. Highly Enantioselective Bromocyclization of Tryptamines and Its Application in the Synthesis of (-)-Chimonanthine, Weiqing Xie*, Guangde Jiang, Huan Liu, Jiadong Hu, Xixian Pan, Hui Zhang, Xiaolong Wan, Yisheng Lai*, Dawei Ma*,Angew. Chem. Int. Ed. 2013,52, 12924-12927

12. Diastereoselective Construction of Continuous All-Carbon Quaternary Centers via Intramolecular Oxidative Coupling Reaction, Weiqing Xie*, Hexiang Wang, Feng Fan, Junshan Tian, Zhiwei Zuo, Weiwei Zi, Kun Gao*, Dawei Ma*,Tetrhedron Lett. 2013, 54, 4392-4396.

11. Intramolecular Oxidative Coupling: Applications in Synthesis of Complex Indole Akaloid Scaffolds, Zhiwei Zuo, Weiwei Zi, Weiqing Xie*, Dawei Ma*, Chin. J. Org. Chem. 2013, 33, 869-876.


10. Asymmetric, Regioselective Bromohydroxylation of 2-Aryl-2-propen-1-ols Catalyzed by Quinine-Derived Catalysts, Ye Zhang, Hui Xing, Weiqing Xie*, Xiaolong Wan, Yisheng Lai*, Dawei Ma*,Adv. Synth. Catal. 2013, 355, 68 – 72.

9. Cascade annulation of malonic diamides: a concise synthesis of polycyclic pyrroloindolines, Feng Fan, Weiqing Xie*, Dawei Ma*,Chem. Commun., 2012, 48, 7571–7573.

8. Total Synthesis of Akuammiline Alkaloid (−)-Vincorine via Intramolecular Oxidative Coupling, Weiwei Zi, Weiqing Xie, Dawei Ma*, J. Am. Chem. Soc., 2012, 132, 9126−9129.


7. Construction of Polycyclic Spiroindolines via an Intramolecular Oxidative Coupling/Cyclization Cascade Reaction Process, Feng Fan, Weiqing Xie*, Dawei Ma*, Org. Lett.2012, 14, 1405–1407.

Ph.D. and Postdoc publications:

6. Rhodium-Catalyzed Annulation of N-Benzoylsulfonamide with Isocyanide through C-H Activation, Chen Zhu*, Weiqing Xie, John, R. Falck, Chem. Eur. J. 2011, 17, 12591 – 12595.

5. Total Synthesis and Absolute Stereochemical Assignment of (−)-Communesin, F, Zhiwei Zuo, Weiqing Xie, Dawei Ma*,J. Am. Chem. Soc., 2010, 132, 13226–13228

4. Total Synthesis and Structure Assignment of Papuamide B, A PotentMarine Cyclodepsipeptide with Anti-HIV Properties, Weiqing Xie, Derong Ding, Weiwei Zi, Guangyu Li, Dawei Ma*,Angew. Chem. Int. Ed. 2008, 47, 2844 –2848.

3. Design of wide-spectrum inhibitors targeting coronavirus main proteases, Haitao Yang, Weiqing Xie, Xiaoyu Xue, Kailin Yang, Jing Ma, Wenxue Liang, Qi Zhao, Zhe Zhou, Duanqing Pei, John Ziebuhr, Rolf Hilgenfeld, Kwok Yung Yuen, Luet Wong, Guangxia Gao, Saijuan Chen, Zhu Chen, Dawei Ma*, Mark Bartlam & Zihe Rao*, PLoS Biology, 2005, 3, 1742-1752.

2. Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that Inhibits mammalian histone deacetylase, Weiqing Xie, Bin Zou, Duanqing Pei, Dawei Ma*,Org. Lett.2005, 7, 2775-2777.

1. An efficient and tunable route to AG7088, a rhinovirus protease inhibitor,   Dawei Ma*, Weiqing Xie, Bin Zou, Qiong Lei, Duanqing Pei, Tetrahedron Lett.2004, 45, 8103-8105
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